MovDisordV3, Main, Exploration, bibRecord, 002108

Psychotic and compulsive symptoms in Parkinson's disease

Identifieur interne : 002108 ( Main/Exploration ); précédent : 002107; suivant : 002109

Psychotic and compulsive symptoms in Parkinson's disease

Auteurs : Dagmar Verbaan [Pays-Bas] ; Stephanie M. Van Rooden [Pays-Bas] ; Martine Visser [Pays-Bas] ; Johan Marinus [Pays-Bas] ; Murat Emre [Turquie] ; Jacobus J. Van Hilten [Pays-Bas]

Source :

Movement Disorders [ 0885-3185 ] ; 2009-04-15.

RBID : ISTEX:17084A6BC27B136E138B9AD8664F97C5EEA10995

Descripteurs français

Pascal (Inist)
- Comportement, Etude cohorte, Maladie de Parkinson, Pathologie du système nerveux, Psychose.

English descriptors

KwdEn :
- Aged, Behavior, Chi-Square Distribution, Cohort Studies, Cohort study, Compulsive Behavior (epidemiology), Compulsive Behavior (etiology), Female, Humans, Male, Middle Aged, Nervous system diseases, Parkinson Disease (complications), Parkinson Disease (epidemiology), Parkinson disease, Parkinson's disease, Psychosis, Psychotic Disorders (epidemiology), Psychotic Disorders (etiology), Regression Analysis, Severity of Illness Index, cohort studies, compulsive behavior, psychosis.
MESH :
- complications : Parkinson Disease.
- epidemiology : Compulsive Behavior, Parkinson Disease, Psychotic Disorders.
- etiology : Compulsive Behavior, Psychotic Disorders.
- Aged, Chi-Square Distribution, Cohort Studies, Female, Humans, Male, Middle Aged, Regression Analysis, Severity of Illness Index.

Abstract

The objective of this study is to evaluate psychiatric symptoms in Parkinson's disease (PD) patients and to assess their relation with other clinical aspects of PD. Psychotic symptoms (PS) and compulsive symptoms (CS) as well as other nonmotor and motor features were evaluated in 353 PD patients. Psychotic and compulsive symptom scores did not correlate significantly. PS occurred in 65% of patients, with item frequencies ranging from 10% (paranoid ideation) to 55% (altered dream phenomena). Regression analysis showed that autonomic impairment accounted for 20% of the 32% explained variance of PS, whereas cognitive problems, depression, daytime sleepiness, and dopamine agonist (DA) dose explained the rest. CS occurred in 19%, with item frequencies of 10% for both sexual preoccupation and compulsive shopping/gambling. Patients with more severe CS (score ≥ 2 on one or both items) were significantly more often men, had a younger age at onset, a higher DA dose and experienced more motor fluctuations compared to the other patients. PS and CS are common but unrelated psychiatric symptoms in PD. The relations found between PS and cognitive problems, depression, daytime sleepiness, and autonomic impairment suggests a resemblance with Dementia with Lewy Bodies. The prominent association between PS and autonomic impairment may be explained by a shared underlying mechanism. Our results confirm previous reports on the profile of patients developing CS, and mechanisms underlying motor fluctuations may also play a role in the development of CS in PD. © 2009 Movement Disorder Society

Url:

https://api.istex.fr/document/17084A6BC27B136E138B9AD8664F97C5EEA10995/fulltext/pdf

DOI: 10.1002/mds.22453

Affiliations:

Le document en format XML

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<author><name sortKey="Visser, Martine" sort="Visser, Martine" uniqKey="Visser M" first="Martine" last="Visser">Martine Visser</name>
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<author><name sortKey="Marinus, Johan" sort="Marinus, Johan" uniqKey="Marinus J" first="Johan" last="Marinus">Johan Marinus</name>
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<front><div type="abstract" xml:lang="en">The objective of this study is to evaluate psychiatric symptoms in Parkinson's disease (PD) patients and to assess their relation with other clinical aspects of PD. Psychotic symptoms (PS) and compulsive symptoms (CS) as well as other nonmotor and motor features were evaluated in 353 PD patients. Psychotic and compulsive symptom scores did not correlate significantly. PS occurred in 65% of patients, with item frequencies ranging from 10% (paranoid ideation) to 55% (altered dream phenomena). Regression analysis showed that autonomic impairment accounted for 20% of the 32% explained variance of PS, whereas cognitive problems, depression, daytime sleepiness, and dopamine agonist (DA) dose explained the rest. CS occurred in 19%, with item frequencies of 10% for both sexual preoccupation and compulsive shopping/gambling. Patients with more severe CS (score ≥ 2 on one or both items) were significantly more often men, had a younger age at onset, a higher DA dose and experienced more motor fluctuations compared to the other patients. PS and CS are common but unrelated psychiatric symptoms in PD. The relations found between PS and cognitive problems, depression, daytime sleepiness, and autonomic impairment suggests a resemblance with Dementia with Lewy Bodies. The prominent association between PS and autonomic impairment may be explained by a shared underlying mechanism. Our results confirm previous reports on the profile of patients developing CS, and mechanisms underlying motor fluctuations may also play a role in the development of CS in PD. © 2009 Movement Disorder Society</div>
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Movement Disorders (revue)

Psychotic and compulsive symptoms in Parkinson's disease

Psychotic and compulsive symptoms in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.